Zydol
Zydol Brand names, Zydol Analogs
Zydol Brand Names Mixture
- No information avaliable
Zydol Chemical_Formula
C16H25NO2
Zydol RX_link
http://www.rxlist.com/cgi/generic/tramadol.htm
Zydol fda sheet
Zydol msds (material safety sheet)
Zydol Synthesis Reference
K. Flick, E. Frankus, U.S. Pat 3,652,589 (1965)
Zydol Molecular Weight
263.375 g/mol
Zydol Melting Point
180-181oC
Zydol H2O Solubility
Soluble in water.
Zydol State
Solid
Zydol LogP
2.951
Zydol Dosage Forms
Tablet
Zydol Indication
Indicated in the treatment of moderate to severe pain.
Zydol Pharmacology
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
Zydol Absorption
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Zydol side effects and Toxicity
LD50=350mg/kg (orally in mice)
Zydol Patient Information
No information avaliable
Zydol Organisms Affected
Humans and other mammals
