Crispin
Crispin Brand names, Crispin Analogs
Crispin Brand Names Mixture
- No information avaliable
Crispin Chemical_Formula
C16H25NO2
Crispin RX_link
http://www.rxlist.com/cgi/generic/tramadol.htm
Crispin fda sheet
Crispin msds (material safety sheet)
Crispin Synthesis Reference
K. Flick, E. Frankus, U.S. Pat 3,652,589 (1965)
Crispin Molecular Weight
263.375 g/mol
Crispin Melting Point
180-181oC
Crispin H2O Solubility
Soluble in water.
Crispin State
Solid
Crispin LogP
2.951
Crispin Dosage Forms
Tablet
Crispin Indication
Indicated in the treatment of moderate to severe pain.
Crispin Pharmacology
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
Crispin Absorption
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Crispin side effects and Toxicity
LD50=350mg/kg (orally in mice)
Crispin Patient Information
No information avaliable
Crispin Organisms Affected
Humans and other mammals
