Tramadol HCl
Tramadol HCl Brand names, Tramadol HCl Analogs
Tramadol HCl Brand Names Mixture
- No information avaliable
Tramadol HCl Chemical_Formula
C16H25NO2
Tramadol HCl RX_link
http://www.rxlist.com/cgi/generic/tramadol.htm
Tramadol HCl fda sheet
Tramadol HCl msds (material safety sheet)
Tramadol HCl Synthesis Reference
K. Flick, E. Frankus, U.S. Pat 3,652,589 (1965)
Tramadol HCl Molecular Weight
263.375 g/mol
Tramadol HCl Melting Point
180-181oC
Tramadol HCl H2O Solubility
Soluble in water.
Tramadol HCl State
Solid
Tramadol HCl LogP
2.951
Tramadol HCl Dosage Forms
Tablet
Tramadol HCl Indication
Indicated in the treatment of moderate to severe pain.
Tramadol HCl Pharmacology
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
Tramadol HCl Absorption
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Tramadol HCl side effects and Toxicity
LD50=350mg/kg (orally in mice)
Tramadol HCl Patient Information
No information avaliable
Tramadol HCl Organisms Affected
Humans and other mammals
