Tramadol hydrochloride
Tramadol hydrochloride Brand names, Tramadol hydrochloride Analogs
Tramadol hydrochloride Brand Names Mixture
- No information avaliable
Tramadol hydrochloride Chemical_Formula
C16H25NO2
Tramadol hydrochloride RX_link
http://www.rxlist.com/cgi/generic/tramadol.htm
Tramadol hydrochloride fda sheet
Tramadol hydrochloride msds (material safety sheet)
Tramadol hydrochloride Synthesis Reference
K. Flick, E. Frankus, U.S. Pat 3,652,589 (1965)
Tramadol hydrochloride Molecular Weight
263.375 g/mol
Tramadol hydrochloride Melting Point
180-181oC
Tramadol hydrochloride H2O Solubility
Soluble in water.
Tramadol hydrochloride State
Solid
Tramadol hydrochloride LogP
2.951
Tramadol hydrochloride Dosage Forms
Tablet
Tramadol hydrochloride Indication
Indicated in the treatment of moderate to severe pain.
Tramadol hydrochloride Pharmacology
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
Tramadol hydrochloride Absorption
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Tramadol hydrochloride side effects and Toxicity
LD50=350mg/kg (orally in mice)
Tramadol hydrochloride Patient Information
No information avaliable
Tramadol hydrochloride Organisms Affected
Humans and other mammals
