Tramal
Tramal Brand names, Tramal Analogs
Tramal Brand Names Mixture
- No information avaliable
Tramal Chemical_Formula
C16H25NO2
Tramal RX_link
http://www.rxlist.com/cgi/generic/tramadol.htm
Tramal fda sheet
Tramal msds (material safety sheet)
Tramal Synthesis Reference
K. Flick, E. Frankus, U.S. Pat 3,652,589 (1965)
Tramal Molecular Weight
263.375 g/mol
Tramal Melting Point
180-181oC
Tramal H2O Solubility
Soluble in water.
Tramal State
Solid
Tramal LogP
2.951
Tramal Dosage Forms
Tablet
Tramal Indication
Indicated in the treatment of moderate to severe pain.
Tramal Pharmacology
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
Tramal Absorption
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Tramal side effects and Toxicity
LD50=350mg/kg (orally in mice)
Tramal Patient Information
No information avaliable
Tramal Organisms Affected
Humans and other mammals
