Ralivia Flashtab
Brand names,
Ralivia Flashtab
Analogs
Ralivia Flashtab
Brand Names Mixture
Ralivia Flashtab
Chemical_Formula
C16H25NO2
Ralivia Flashtab
RX_link
http://www.rxlist.com/cgi/generic/tramadol.htm
Ralivia Flashtab
fda sheet
Ralivia Flashtab
msds (material safety sheet)
Ralivia Flashtab
Synthesis Reference
K. Flick, E. Frankus, U.S. Pat 3,652,589 (1965)
Ralivia Flashtab
Molecular Weight
263.375 g/mol
Ralivia Flashtab
Melting Point
180-181oC
Ralivia Flashtab
H2O Solubility
Soluble in water.
Ralivia Flashtab
State
Solid
Ralivia Flashtab
LogP
2.951
Ralivia Flashtab
Dosage Forms
Tablet
Ralivia Flashtab
Indication
Indicated in the treatment of moderate to severe pain.
Ralivia Flashtab
Pharmacology
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
Ralivia Flashtab
Absorption
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Ralivia Flashtab
side effects and Toxicity
LD50=350mg/kg (orally in mice)
Ralivia Flashtab
Patient Information
No information avaliable
Ralivia Flashtab
Organisms Affected
Humans and other mammals