Tramadol
Tramadol Brand names, Tramadol Analogs
Tramadol Brand Names Mixture
- No information avaliable
Tramadol Chemical_Formula
C16H25NO2
Tramadol RX_link
http://www.rxlist.com/cgi/generic/tramadol.htm
Tramadol fda sheet
Tramadol msds (material safety sheet)
Tramadol Synthesis Reference
K. Flick, E. Frankus, U.S. Pat 3,652,589 (1965)
Tramadol Molecular Weight
263.375 g/mol
Tramadol Melting Point
180-181oC
Tramadol H2O Solubility
Soluble in water.
Tramadol State
Solid
Tramadol LogP
2.951
Tramadol Dosage Forms
Tablet
Tramadol Indication
Indicated in the treatment of moderate to severe pain.
Tramadol Pharmacology
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
Tramadol Absorption
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Tramadol side effects and Toxicity
LD50=350mg/kg (orally in mice)
Tramadol Patient Information
No information avaliable
Tramadol Organisms Affected
Humans and other mammals
