Terbutaline
Terbutaline Brand names, Terbutaline Analogs
Terbutaline Brand Names Mixture
- No information avaliable
Terbutaline Chemical_Formula
C12H19NO3
Terbutaline RX_link
http://www.rxlist.com/cgi/generic3/terbutaline.htm
Terbutaline fda sheet
Terbutaline msds (material safety sheet)
Terbutaline Synthesis Reference
K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)
Terbutaline Molecular Weight
225.284 g/mol
Terbutaline Melting Point
119-122 oC
Terbutaline H2O Solubility
213 mg/mL
Terbutaline State
Solid
Terbutaline LogP
1.567
Terbutaline Dosage Forms
Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection
Terbutaline Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Terbutaline Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Terbutaline Absorption
No information avaliable
Terbutaline side effects and Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Terbutaline Patient Information
Terbutaline Organisms Affected
Humans and other mammals
