Bricar
Bricar Brand names, Bricar Analogs
Bricar Brand Names Mixture
- No information avaliable
Bricar Chemical_Formula
C12H19NO3
Bricar RX_link
http://www.rxlist.com/cgi/generic3/terbutaline.htm
Bricar fda sheet
Bricar msds (material safety sheet)
Bricar Synthesis Reference
K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)
Bricar Molecular Weight
225.284 g/mol
Bricar Melting Point
119-122 oC
Bricar H2O Solubility
213 mg/mL
Bricar State
Solid
Bricar LogP
1.567
Bricar Dosage Forms
Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection
Bricar Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Bricar Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Bricar Absorption
No information avaliable
Bricar side effects and Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Bricar Patient Information
Bricar Organisms Affected
Humans and other mammals
