Brican
Brican Brand names, Brican Analogs
Brican Brand Names Mixture
- No information avaliable
Brican Chemical_Formula
C12H19NO3
Brican RX_link
http://www.rxlist.com/cgi/generic3/terbutaline.htm
Brican fda sheet
Brican msds (material safety sheet)
Brican Synthesis Reference
K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)
Brican Molecular Weight
225.284 g/mol
Brican Melting Point
119-122 oC
Brican H2O Solubility
213 mg/mL
Brican State
Solid
Brican LogP
1.567
Brican Dosage Forms
Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection
Brican Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Brican Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Brican Absorption
No information avaliable
Brican side effects and Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Brican Patient Information
Brican Organisms Affected
Humans and other mammals
