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Brican Brand names, Brican Analogs

Brican Brand Names Mixture

  • No information avaliable

Brican Chemical_Formula

C12H19NO3

Brican RX_link

http://www.rxlist.com/cgi/generic3/terbutaline.htm

Brican fda sheet

Brican msds (material safety sheet)

Brican MSDS

Brican Synthesis Reference

K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)

Brican Molecular Weight

225.284 g/mol

Brican Melting Point

119-122 oC

Brican H2O Solubility

213 mg/mL

Brican State

Solid

Brican LogP

1.567

Brican Dosage Forms

Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection

Brican Indication

For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.

Brican Pharmacology

Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Brican Absorption

No information avaliable

Brican side effects and Toxicity

Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg

Brican Patient Information

Brican Organisms Affected

Humans and other mammals