Terbutalin
Terbutalin Brand names, Terbutalin Analogs
Terbutalin Brand Names Mixture
- No information avaliable
Terbutalin Chemical_Formula
C12H19NO3
Terbutalin RX_link
http://www.rxlist.com/cgi/generic3/terbutaline.htm
Terbutalin fda sheet
Terbutalin msds (material safety sheet)
Terbutalin Synthesis Reference
K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)
Terbutalin Molecular Weight
225.284 g/mol
Terbutalin Melting Point
119-122 oC
Terbutalin H2O Solubility
213 mg/mL
Terbutalin State
Solid
Terbutalin LogP
1.567
Terbutalin Dosage Forms
Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection
Terbutalin Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Terbutalin Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Terbutalin Absorption
No information avaliable
Terbutalin side effects and Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Terbutalin Patient Information
Terbutalin Organisms Affected
Humans and other mammals
