Bricanyl
Bricanyl Brand names, Bricanyl Analogs
Bricanyl Brand Names Mixture
- No information avaliable
Bricanyl Chemical_Formula
C12H19NO3
Bricanyl RX_link
http://www.rxlist.com/cgi/generic3/terbutaline.htm
Bricanyl fda sheet
Bricanyl msds (material safety sheet)
Bricanyl Synthesis Reference
K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)
Bricanyl Molecular Weight
225.284 g/mol
Bricanyl Melting Point
119-122 oC
Bricanyl H2O Solubility
213 mg/mL
Bricanyl State
Solid
Bricanyl LogP
1.567
Bricanyl Dosage Forms
Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection
Bricanyl Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Bricanyl Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Bricanyl Absorption
No information avaliable
Bricanyl side effects and Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Bricanyl Patient Information
Bricanyl Organisms Affected
Humans and other mammals
