Bricyn
Bricyn Brand names, Bricyn Analogs
Bricyn Brand Names Mixture
- No information avaliable
Bricyn Chemical_Formula
C12H19NO3
Bricyn RX_link
http://www.rxlist.com/cgi/generic3/terbutaline.htm
Bricyn fda sheet
Bricyn msds (material safety sheet)
Bricyn Synthesis Reference
K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)
Bricyn Molecular Weight
225.284 g/mol
Bricyn Melting Point
119-122 oC
Bricyn H2O Solubility
213 mg/mL
Bricyn State
Solid
Bricyn LogP
1.567
Bricyn Dosage Forms
Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection
Bricyn Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Bricyn Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Bricyn Absorption
No information avaliable
Bricyn side effects and Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Bricyn Patient Information
Bricyn Organisms Affected
Humans and other mammals
