Bricaril
Bricaril Brand names, Bricaril Analogs
Bricaril Brand Names Mixture
- No information avaliable
Bricaril Chemical_Formula
C12H19NO3
Bricaril RX_link
http://www.rxlist.com/cgi/generic3/terbutaline.htm
Bricaril fda sheet
Bricaril msds (material safety sheet)
Bricaril Synthesis Reference
K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)
Bricaril Molecular Weight
225.284 g/mol
Bricaril Melting Point
119-122 oC
Bricaril H2O Solubility
213 mg/mL
Bricaril State
Solid
Bricaril LogP
1.567
Bricaril Dosage Forms
Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection
Bricaril Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Bricaril Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Bricaril Absorption
No information avaliable
Bricaril side effects and Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Bricaril Patient Information
Bricaril Organisms Affected
Humans and other mammals
