Brethine
Brethine Brand names, Brethine Analogs
Brethine Brand Names Mixture
- No information avaliable
Brethine Chemical_Formula
C12H19NO3
Brethine RX_link
http://www.rxlist.com/cgi/generic3/terbutaline.htm
Brethine fda sheet
Brethine msds (material safety sheet)
Brethine Synthesis Reference
K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)
Brethine Molecular Weight
225.284 g/mol
Brethine Melting Point
119-122 oC
Brethine H2O Solubility
213 mg/mL
Brethine State
Solid
Brethine LogP
1.567
Brethine Dosage Forms
Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection
Brethine Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Brethine Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Brethine Absorption
No information avaliable
Brethine side effects and Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Brethine Patient Information
Brethine Organisms Affected
Humans and other mammals
