Brethaire
Brethaire Brand names, Brethaire Analogs
Brethaire Brand Names Mixture
- No information avaliable
Brethaire Chemical_Formula
C12H19NO3
Brethaire RX_link
http://www.rxlist.com/cgi/generic3/terbutaline.htm
Brethaire fda sheet
Brethaire msds (material safety sheet)
Brethaire Synthesis Reference
K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)
Brethaire Molecular Weight
225.284 g/mol
Brethaire Melting Point
119-122 oC
Brethaire H2O Solubility
213 mg/mL
Brethaire State
Solid
Brethaire LogP
1.567
Brethaire Dosage Forms
Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection
Brethaire Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Brethaire Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Brethaire Absorption
No information avaliable
Brethaire side effects and Toxicity
Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Brethaire Patient Information
Brethaire Organisms Affected
Humans and other mammals
