Rythmodan
Brand names,
Rythmodan
Analogs
Rythmodan
Brand Names Mixture
Rythmodan
Chemical_Formula
C21H29N3O
Rythmodan
RX_link
http://www.rxlist.com/cgi/generic2/disopyr.htm
Rythmodan
fda sheet
Rythmodan
msds (material safety sheet)
Rythmodan
Synthesis Reference
No information avaliable
Rythmodan
Molecular Weight
339.475 g/mol
Rythmodan
Melting Point
94.5-95 oC
Rythmodan
H2O Solubility
44.9 mg/L
Rythmodan
State
Solid
Rythmodan
LogP
3.972
Rythmodan
Dosage Forms
Capsule; Tablet (extended-release)
Rythmodan
Indication
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias.
Rythmodan
Pharmacology
Disopyramide is an antiarrhythmic drug indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia that are life-threatening. In man, Disopyramide at therapeutic plasma levels shortens the sinus node recovery time, lengthens the effective refractory period of the atrium, and has a minimal effect on the effective refractory period of the AV node. Little effect has been shown on AV-nodal and His-Purkinje conduction times or QRS duration. However, prolongation of conduction in accessory pathways occurs.
Rythmodan
Absorption
Nearly complete
Rythmodan
side effects and Toxicity
LD50=580 mg/kg in rats
Rythmodan
Patient Information
No information avaliable
Rythmodan
Organisms Affected
Humans and other mammals