Disopiramida [Inn-Spanish]
Brand names,
Disopiramida [Inn-Spanish]
Analogs
Disopiramida [Inn-Spanish]
Brand Names Mixture
Disopiramida [Inn-Spanish]
Chemical_Formula
C21H29N3O
Disopiramida [Inn-Spanish]
RX_link
http://www.rxlist.com/cgi/generic2/disopyr.htm
Disopiramida [Inn-Spanish]
fda sheet
Disopiramida [Inn-Spanish]
msds (material safety sheet)
Disopiramida [Inn-Spanish]
Synthesis Reference
No information avaliable
Disopiramida [Inn-Spanish]
Molecular Weight
339.475 g/mol
Disopiramida [Inn-Spanish]
Melting Point
94.5-95 oC
Disopiramida [Inn-Spanish]
H2O Solubility
44.9 mg/L
Disopiramida [Inn-Spanish]
State
Solid
Disopiramida [Inn-Spanish]
LogP
3.972
Disopiramida [Inn-Spanish]
Dosage Forms
Capsule; Tablet (extended-release)
Disopiramida [Inn-Spanish]
Indication
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias.
Disopiramida [Inn-Spanish]
Pharmacology
Disopyramide is an antiarrhythmic drug indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia that are life-threatening. In man, Disopyramide at therapeutic plasma levels shortens the sinus node recovery time, lengthens the effective refractory period of the atrium, and has a minimal effect on the effective refractory period of the AV node. Little effect has been shown on AV-nodal and His-Purkinje conduction times or QRS duration. However, prolongation of conduction in accessory pathways occurs.
Disopiramida [Inn-Spanish]
Absorption
Nearly complete
Disopiramida [Inn-Spanish]
side effects and Toxicity
LD50=580 mg/kg in rats
Disopiramida [Inn-Spanish]
Patient Information
No information avaliable
Disopiramida [Inn-Spanish]
Organisms Affected
Humans and other mammals