Isorythm
Brand names,
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Analogs
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Brand Names Mixture
Isorythm
Chemical_Formula
C21H29N3O
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RX_link
http://www.rxlist.com/cgi/generic2/disopyr.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
339.475 g/mol
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Melting Point
94.5-95 oC
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H2O Solubility
44.9 mg/L
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State
Solid
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LogP
3.972
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Dosage Forms
Capsule; Tablet (extended-release)
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Indication
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias.
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Pharmacology
Disopyramide is an antiarrhythmic drug indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia that are life-threatening. In man, Disopyramide at therapeutic plasma levels shortens the sinus node recovery time, lengthens the effective refractory period of the atrium, and has a minimal effect on the effective refractory period of the AV node. Little effect has been shown on AV-nodal and His-Purkinje conduction times or QRS duration. However, prolongation of conduction in accessory pathways occurs.
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Absorption
Nearly complete
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side effects and Toxicity
LD50=580 mg/kg in rats
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals