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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C21H25ClN2O3
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RX_link
http://www.rxlist.com/cgi/generic/cetiriz.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
E. Baltes et al., U.S. Pat. 4,525,358 (1985)
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Molecular Weight
388.888 g/mol
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Melting Point
110-115oC
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H2O Solubility
101 mg/L
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State
solid
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LogP
3.238
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Dosage Forms
Tablets
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Indication
For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria
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Pharmacology
Cetirizine, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis.
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Absorption
mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine
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side effects and Toxicity
Somnolence (sleepiness or unusual drowsiness), restlessness, irritability
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Patient Information
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Organisms Affected
Humans and other mammals