RAL
RAL Brand names, RAL Analogs
RAL Brand Names Mixture
- No information avaliable
RAL Chemical_Formula
C16H25NO2
RAL RX_link
http://www.rxlist.com/cgi/generic/tramadol.htm
RAL fda sheet
RAL msds (material safety sheet)
RAL Synthesis Reference
K. Flick, E. Frankus, U.S. Pat 3,652,589 (1965)
RAL Molecular Weight
263.375 g/mol
RAL Melting Point
180-181oC
RAL H2O Solubility
Soluble in water.
RAL State
Solid
RAL LogP
2.951
RAL Dosage Forms
Tablet
RAL Indication
Indicated in the treatment of moderate to severe pain.
RAL Pharmacology
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
RAL Absorption
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
RAL side effects and Toxicity
LD50=350mg/kg (orally in mice)
RAL Patient Information
No information avaliable
RAL Organisms Affected
Humans and other mammals
