Pydox
Brand names,
Pydox
Analogs
Pydox
Brand Names Mixture
Pydox
Chemical_Formula
C8H11NO3
Pydox
RX_link
No information avaliable
Pydox
fda sheet
Pydox
msds (material safety sheet)
Pydox
Synthesis Reference
No information avaliable
Pydox
Molecular Weight
169.178 g/mol
Pydox
Melting Point
207 oC
Pydox
H2O Solubility
2.2E+005 mg/L
Pydox
State
Solid
Pydox
LogP
-0.784
Pydox
Dosage Forms
Capsules
Pydox
Indication
For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
Pydox
Pharmacology
Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Pydox
Absorption
Readily absorbed
Pydox
side effects and Toxicity
Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Pydox
Patient Information
No information avaliable
Pydox
Organisms Affected
Humans and other mammals