Pyridoxinum Hydrochloricum
Brand names,
Pyridoxinum Hydrochloricum
Analogs
Pyridoxinum Hydrochloricum
Brand Names Mixture
Pyridoxinum Hydrochloricum
Chemical_Formula
C8H11NO3
Pyridoxinum Hydrochloricum
RX_link
No information avaliable
Pyridoxinum Hydrochloricum
fda sheet
Pyridoxinum Hydrochloricum
msds (material safety sheet)
Pyridoxinum Hydrochloricum
Synthesis Reference
No information avaliable
Pyridoxinum Hydrochloricum
Molecular Weight
169.178 g/mol
Pyridoxinum Hydrochloricum
Melting Point
207 oC
Pyridoxinum Hydrochloricum
H2O Solubility
2.2E+005 mg/L
Pyridoxinum Hydrochloricum
State
Solid
Pyridoxinum Hydrochloricum
LogP
-0.784
Pyridoxinum Hydrochloricum
Dosage Forms
Capsules
Pyridoxinum Hydrochloricum
Indication
For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
Pyridoxinum Hydrochloricum
Pharmacology
Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Pyridoxinum Hydrochloricum
Absorption
Readily absorbed
Pyridoxinum Hydrochloricum
side effects and Toxicity
Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Pyridoxinum Hydrochloricum
Patient Information
No information avaliable
Pyridoxinum Hydrochloricum
Organisms Affected
Humans and other mammals