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Nestrex Brand names, Nestrex Analogs

Nestrex Brand Names Mixture

  • No information avaliable

Nestrex Chemical_Formula


Nestrex RX_link

No information avaliable

Nestrex fda sheet

Nestrex msds (material safety sheet)

Nestrex MSDS

Nestrex Synthesis Reference

No information avaliable

Nestrex Molecular Weight

169.178 g/mol

Nestrex Melting Point

207 oC

Nestrex H2O Solubility

2.2E+005 mg/L

Nestrex State


Nestrex LogP


Nestrex Dosage Forms


Nestrex Indication

For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.

Nestrex Pharmacology

Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.

Nestrex Absorption

Readily absorbed

Nestrex side effects and Toxicity

Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.

Nestrex Patient Information

No information avaliable

Nestrex Organisms Affected

Humans and other mammals