Pyridoxine-HCl Microencapsulated
Brand names,
Pyridoxine-HCl Microencapsulated
Analogs
Pyridoxine-HCl Microencapsulated
Brand Names Mixture
Pyridoxine-HCl Microencapsulated
Chemical_Formula
C8H11NO3
Pyridoxine-HCl Microencapsulated
RX_link
No information avaliable
Pyridoxine-HCl Microencapsulated
fda sheet
Pyridoxine-HCl Microencapsulated
msds (material safety sheet)
Pyridoxine-HCl Microencapsulated
Synthesis Reference
No information avaliable
Pyridoxine-HCl Microencapsulated
Molecular Weight
169.178 g/mol
Pyridoxine-HCl Microencapsulated
Melting Point
207 oC
Pyridoxine-HCl Microencapsulated
H2O Solubility
2.2E+005 mg/L
Pyridoxine-HCl Microencapsulated
State
Solid
Pyridoxine-HCl Microencapsulated
LogP
-0.784
Pyridoxine-HCl Microencapsulated
Dosage Forms
Capsules
Pyridoxine-HCl Microencapsulated
Indication
For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
Pyridoxine-HCl Microencapsulated
Pharmacology
Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Pyridoxine-HCl Microencapsulated
Absorption
Readily absorbed
Pyridoxine-HCl Microencapsulated
side effects and Toxicity
Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Pyridoxine-HCl Microencapsulated
Patient Information
No information avaliable
Pyridoxine-HCl Microencapsulated
Organisms Affected
Humans and other mammals