Hexabione hydrochloride
Brand names,
Hexabione hydrochloride
Analogs
Hexabione hydrochloride
Brand Names Mixture
Hexabione hydrochloride
Chemical_Formula
C8H11NO3
Hexabione hydrochloride
RX_link
No information avaliable
Hexabione hydrochloride
fda sheet
Hexabione hydrochloride
msds (material safety sheet)
Hexabione hydrochloride
Synthesis Reference
No information avaliable
Hexabione hydrochloride
Molecular Weight
169.178 g/mol
Hexabione hydrochloride
Melting Point
207 oC
Hexabione hydrochloride
H2O Solubility
2.2E+005 mg/L
Hexabione hydrochloride
State
Solid
Hexabione hydrochloride
LogP
-0.784
Hexabione hydrochloride
Dosage Forms
Capsules
Hexabione hydrochloride
Indication
For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
Hexabione hydrochloride
Pharmacology
Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Hexabione hydrochloride
Absorption
Readily absorbed
Hexabione hydrochloride
side effects and Toxicity
Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Hexabione hydrochloride
Patient Information
No information avaliable
Hexabione hydrochloride
Organisms Affected
Humans and other mammals