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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C18H28N2O4
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RX_link
http://www.rxlist.com/cgi/generic2/ace.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
336.426 g/mol
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Melting Point
119-123 oC
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H2O Solubility
259 mg/L
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State
Solid
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LogP
2.356
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Dosage Forms
Tablet; Capsule (200 mg and 400 mg)
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Indication
For the management of hypertension and ventricular premature beats in adults.
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Pharmacology
Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Acebutolol has less antagonistic effects on peripheral vascular ß2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol.
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Absorption
Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound. In
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side effects and Toxicity
Symptoms of overdose include extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm, and hypoglycemia.
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Patient Information
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Organisms Affected
Humans and other mammals