Monitan
Brand names,
Monitan
Analogs
Monitan
Brand Names Mixture
Monitan
Chemical_Formula
C18H28N2O4
Monitan
RX_link
http://www.rxlist.com/cgi/generic2/ace.htm
Monitan
fda sheet
Monitan
msds (material safety sheet)
Monitan
Synthesis Reference
No information avaliable
Monitan
Molecular Weight
336.426 g/mol
Monitan
Melting Point
119-123 oC
Monitan
H2O Solubility
259 mg/L
Monitan
State
Solid
Monitan
LogP
2.356
Monitan
Dosage Forms
Tablet; Capsule (200 mg and 400 mg)
Monitan
Indication
For the management of hypertension and ventricular premature beats in adults.
Monitan
Pharmacology
Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Acebutolol has less antagonistic effects on peripheral vascular ß2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol.
Monitan
Absorption
Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound. In
Monitan
side effects and Toxicity
Symptoms of overdose include extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm, and hypoglycemia.
Monitan
Patient Information
Monitan
Organisms Affected
Humans and other mammals