Sectral

• Adrenergic beta-Antagonists
• Anti-Arrhythmia Agents
• Antihypertensive Agents
• ATC:C07AB04

• Acebrutololum [INN-Latin]
• Acebutolol HCL
• Acebutolol [USAN:BAN:INN]
• Acebutololo
• Acebutololum [INN-Latin]
• Acetobutolol
• Acetobutolol [INN-Spanish]
• Monitan
• Neptal
• Prent
• Sectral
• dl-Acebutolol

• No information avaliable

C₁₈H₂₈N₂O₄

http://www.rxlist.com/cgi/generic2/ace.htm

No information avaliable

336.426 g/mol

119-123 ^oC

259 mg/L

Solid

2.356

Tablet; Capsule (200 mg and 400 mg)

For the management of hypertension and ventricular premature beats in adults.

Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Acebutolol has less antagonistic effects on peripheral vascular ß2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol.

Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound. In

Symptoms of overdose include extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm, and hypoglycemia.

Humans and other mammals