Acetobutolol [INN-Spanish]
Brand names,
Acetobutolol [INN-Spanish]
Analogs
Acetobutolol [INN-Spanish]
Brand Names Mixture
Acetobutolol [INN-Spanish]
Chemical_Formula
C18H28N2O4
Acetobutolol [INN-Spanish]
RX_link
http://www.rxlist.com/cgi/generic2/ace.htm
Acetobutolol [INN-Spanish]
fda sheet
Acetobutolol [INN-Spanish]
msds (material safety sheet)
Acetobutolol [INN-Spanish]
Synthesis Reference
No information avaliable
Acetobutolol [INN-Spanish]
Molecular Weight
336.426 g/mol
Acetobutolol [INN-Spanish]
Melting Point
119-123 oC
Acetobutolol [INN-Spanish]
H2O Solubility
259 mg/L
Acetobutolol [INN-Spanish]
State
Solid
Acetobutolol [INN-Spanish]
LogP
2.356
Acetobutolol [INN-Spanish]
Dosage Forms
Tablet; Capsule (200 mg and 400 mg)
Acetobutolol [INN-Spanish]
Indication
For the management of hypertension and ventricular premature beats in adults.
Acetobutolol [INN-Spanish]
Pharmacology
Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Acebutolol has less antagonistic effects on peripheral vascular ß2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol.
Acetobutolol [INN-Spanish]
Absorption
Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound. In
Acetobutolol [INN-Spanish]
side effects and Toxicity
Symptoms of overdose include extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm, and hypoglycemia.
Acetobutolol [INN-Spanish]
Patient Information
Acetobutolol [INN-Spanish]
Organisms Affected
Humans and other mammals