Pob Hcl
Brand names,
Pob Hcl
Analogs
Pob Hcl
Brand Names Mixture
Pob Hcl
Chemical_Formula
C18H22ClNO
Pob Hcl
RX_link
http://www.rxlist.com/cgi/generic3/phenoxybenz.htm
Pob Hcl
fda sheet
Pob Hcl
msds (material safety sheet)
Pob Hcl
Synthesis Reference
No information avaliable
Pob Hcl
Molecular Weight
303.826 g/mol
Pob Hcl
Melting Point
39 oC
Pob Hcl
H2O Solubility
No information avaliable
Pob Hcl
State
Solid
Pob Hcl
LogP
4.601
Pob Hcl
Dosage Forms
No information avaliable
Pob Hcl
Indication
For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.
Pob Hcl
Pharmacology
Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phenoxybenzamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Pob Hcl
Absorption
No information avaliable
Pob Hcl
side effects and Toxicity
No information avaliable
Pob Hcl
Patient Information
No information avaliable
Pob Hcl
Organisms Affected
Humans and other mammals