Phenoxybenzaminum [Inn-Latin]
Brand names,
Phenoxybenzaminum [Inn-Latin]
Analogs
Phenoxybenzaminum [Inn-Latin]
Brand Names Mixture
Phenoxybenzaminum [Inn-Latin]
Chemical_Formula
C18H22ClNO
Phenoxybenzaminum [Inn-Latin]
RX_link
http://www.rxlist.com/cgi/generic3/phenoxybenz.htm
Phenoxybenzaminum [Inn-Latin]
fda sheet
Phenoxybenzaminum [Inn-Latin]
msds (material safety sheet)
Phenoxybenzaminum [Inn-Latin]
Synthesis Reference
No information avaliable
Phenoxybenzaminum [Inn-Latin]
Molecular Weight
303.826 g/mol
Phenoxybenzaminum [Inn-Latin]
Melting Point
39 oC
Phenoxybenzaminum [Inn-Latin]
H2O Solubility
No information avaliable
Phenoxybenzaminum [Inn-Latin]
State
Solid
Phenoxybenzaminum [Inn-Latin]
LogP
4.601
Phenoxybenzaminum [Inn-Latin]
Dosage Forms
No information avaliable
Phenoxybenzaminum [Inn-Latin]
Indication
For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.
Phenoxybenzaminum [Inn-Latin]
Pharmacology
Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phenoxybenzamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Phenoxybenzaminum [Inn-Latin]
Absorption
No information avaliable
Phenoxybenzaminum [Inn-Latin]
side effects and Toxicity
No information avaliable
Phenoxybenzaminum [Inn-Latin]
Patient Information
No information avaliable
Phenoxybenzaminum [Inn-Latin]
Organisms Affected
Humans and other mammals