Dibenyline
Brand names,
Dibenyline
Analogs
Dibenyline
Brand Names Mixture
Dibenyline
Chemical_Formula
C18H22ClNO
Dibenyline
RX_link
http://www.rxlist.com/cgi/generic3/phenoxybenz.htm
Dibenyline
fda sheet
Dibenyline
msds (material safety sheet)
Dibenyline
Synthesis Reference
No information avaliable
Dibenyline
Molecular Weight
303.826 g/mol
Dibenyline
Melting Point
39 oC
Dibenyline
H2O Solubility
No information avaliable
Dibenyline
State
Solid
Dibenyline
LogP
4.601
Dibenyline
Dosage Forms
No information avaliable
Dibenyline
Indication
For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.
Dibenyline
Pharmacology
Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phenoxybenzamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Dibenyline
Absorption
No information avaliable
Dibenyline
side effects and Toxicity
No information avaliable
Dibenyline
Patient Information
No information avaliable
Dibenyline
Organisms Affected
Humans and other mammals