Dibenylin
Brand names,
Dibenylin
Analogs
Dibenylin
Brand Names Mixture
Dibenylin
Chemical_Formula
C18H22ClNO
Dibenylin
RX_link
http://www.rxlist.com/cgi/generic3/phenoxybenz.htm
Dibenylin
fda sheet
Dibenylin
msds (material safety sheet)
Dibenylin
Synthesis Reference
No information avaliable
Dibenylin
Molecular Weight
303.826 g/mol
Dibenylin
Melting Point
39 oC
Dibenylin
H2O Solubility
No information avaliable
Dibenylin
State
Solid
Dibenylin
LogP
4.601
Dibenylin
Dosage Forms
No information avaliable
Dibenylin
Indication
For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.
Dibenylin
Pharmacology
Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phenoxybenzamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Dibenylin
Absorption
No information avaliable
Dibenylin
side effects and Toxicity
No information avaliable
Dibenylin
Patient Information
No information avaliable
Dibenylin
Organisms Affected
Humans and other mammals