Pentostatin
Pentostatin Brand names, Pentostatin Analogs
Pentostatin Brand Names Mixture
- No information avaliable
Pentostatin Chemical_Formula
C11H16N4O4
Pentostatin RX_link
No information avaliable
Pentostatin fda sheet
Pentostatin msds (material safety sheet)
Pentostatin Synthesis Reference
Showalter, HD et al., J. Med. Chem. 26:1478 (1983)
Pentostatin Molecular Weight
268.269 g/mol
Pentostatin Melting Point
220 oC
Pentostatin H2O Solubility
30 mg/mL
Pentostatin State
Solid
Pentostatin LogP
-1.58
Pentostatin Dosage Forms
Powder for solution
Pentostatin Indication
For the treatment of hairy cell leukaemia refractory to alpha interferon.
Pentostatin Pharmacology
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
Pentostatin Absorption
Not absorbed orally, crosses blood brain barrier.
Pentostatin side effects and Toxicity
LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
Pentostatin Patient Information
Pentostatin Organisms Affected
Humans and other mammals
