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Pentostatin Brand names, Pentostatin Analogs

Pentostatin Brand Names Mixture

  • No information avaliable

Pentostatin Chemical_Formula


Pentostatin RX_link

No information avaliable

Pentostatin fda sheet

Pentostatin msds (material safety sheet)

Pentostatin MSDS

Pentostatin Synthesis Reference

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

Pentostatin Molecular Weight

268.269 g/mol

Pentostatin Melting Point

220 oC

Pentostatin H2O Solubility

30 mg/mL

Pentostatin State


Pentostatin LogP


Pentostatin Dosage Forms

Powder for solution

Pentostatin Indication

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Pentostatin Pharmacology

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Pentostatin Absorption

Not absorbed orally, crosses blood brain barrier.

Pentostatin side effects and Toxicity

LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

Pentostatin Patient Information

BC Cancer

Pentostatin Organisms Affected

Humans and other mammals