Co-V
Co-V Brand names, Co-V Analogs
Co-V Brand Names Mixture
- No information avaliable
Co-V Chemical_Formula
C11H16N4O4
Co-V RX_link
No information avaliable
Co-V fda sheet
Co-V msds (material safety sheet)
Co-V Synthesis Reference
Showalter, HD et al., J. Med. Chem. 26:1478 (1983)
Co-V Molecular Weight
268.269 g/mol
Co-V Melting Point
220 oC
Co-V H2O Solubility
30 mg/mL
Co-V State
Solid
Co-V LogP
-1.58
Co-V Dosage Forms
Powder for solution
Co-V Indication
For the treatment of hairy cell leukaemia refractory to alpha interferon.
Co-V Pharmacology
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
Co-V Absorption
Not absorbed orally, crosses blood brain barrier.
Co-V side effects and Toxicity
LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
Co-V Patient Information
Co-V Organisms Affected
Humans and other mammals
