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Co-V Brand names, Co-V Analogs

Co-V Brand Names Mixture

  • No information avaliable

Co-V Chemical_Formula


Co-V RX_link

No information avaliable

Co-V fda sheet

Co-V msds (material safety sheet)


Co-V Synthesis Reference

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

Co-V Molecular Weight

268.269 g/mol

Co-V Melting Point

220 oC

Co-V H2O Solubility

30 mg/mL

Co-V State


Co-V LogP


Co-V Dosage Forms

Powder for solution

Co-V Indication

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Co-V Pharmacology

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Co-V Absorption

Not absorbed orally, crosses blood brain barrier.

Co-V side effects and Toxicity

LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

Co-V Patient Information

BC Cancer

Co-V Organisms Affected

Humans and other mammals