PD-ADI en es it fr

PD-ADI Brand names, PD-ADI Analogs

PD-ADI Brand Names Mixture

  • No information avaliable

PD-ADI Chemical_Formula


PD-ADI RX_link

No information avaliable

PD-ADI fda sheet


PD-ADI msds (material safety sheet)


PD-ADI Synthesis Reference

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

PD-ADI Molecular Weight

268.269 g/mol

PD-ADI Melting Point

220 oC

PD-ADI H2O Solubility

30 mg/mL

PD-ADI State




PD-ADI Dosage Forms

Powder for solution

PD-ADI Indication

For the treatment of hairy cell leukaemia refractory to alpha interferon.

PD-ADI Pharmacology

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

PD-ADI Absorption

Not absorbed orally, crosses blood brain barrier.

PD-ADI side effects and Toxicity

LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

PD-ADI Patient Information

BC Cancer

PD-ADI Organisms Affected

Humans and other mammals