PD-ADI
PD-ADI Brand names, PD-ADI Analogs
PD-ADI Brand Names Mixture
- No information avaliable
PD-ADI Chemical_Formula
C11H16N4O4
PD-ADI RX_link
No information avaliable
PD-ADI fda sheet
PD-ADI msds (material safety sheet)
PD-ADI Synthesis Reference
Showalter, HD et al., J. Med. Chem. 26:1478 (1983)
PD-ADI Molecular Weight
268.269 g/mol
PD-ADI Melting Point
220 oC
PD-ADI H2O Solubility
30 mg/mL
PD-ADI State
Solid
PD-ADI LogP
-1.58
PD-ADI Dosage Forms
Powder for solution
PD-ADI Indication
For the treatment of hairy cell leukaemia refractory to alpha interferon.
PD-ADI Pharmacology
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
PD-ADI Absorption
Not absorbed orally, crosses blood brain barrier.
PD-ADI side effects and Toxicity
LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
PD-ADI Patient Information
PD-ADI Organisms Affected
Humans and other mammals
