Vidarbine
Vidarbine Brand names, Vidarbine Analogs
Vidarbine Brand Names Mixture
- No information avaliable
Vidarbine Chemical_Formula
C11H16N4O4
Vidarbine RX_link
No information avaliable
Vidarbine fda sheet
Vidarbine msds (material safety sheet)
Vidarbine Synthesis Reference
Showalter, HD et al., J. Med. Chem. 26:1478 (1983)
Vidarbine Molecular Weight
268.269 g/mol
Vidarbine Melting Point
220 oC
Vidarbine H2O Solubility
30 mg/mL
Vidarbine State
Solid
Vidarbine LogP
-1.58
Vidarbine Dosage Forms
Powder for solution
Vidarbine Indication
For the treatment of hairy cell leukaemia refractory to alpha interferon.
Vidarbine Pharmacology
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
Vidarbine Absorption
Not absorbed orally, crosses blood brain barrier.
Vidarbine side effects and Toxicity
LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
Vidarbine Patient Information
Vidarbine Organisms Affected
Humans and other mammals
