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Vidarbine Brand names, Vidarbine Analogs

Vidarbine Brand Names Mixture

  • No information avaliable

Vidarbine Chemical_Formula


Vidarbine RX_link

No information avaliable

Vidarbine fda sheet

Vidarbine msds (material safety sheet)

Vidarbine MSDS

Vidarbine Synthesis Reference

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

Vidarbine Molecular Weight

268.269 g/mol

Vidarbine Melting Point

220 oC

Vidarbine H2O Solubility

30 mg/mL

Vidarbine State


Vidarbine LogP


Vidarbine Dosage Forms

Powder for solution

Vidarbine Indication

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Vidarbine Pharmacology

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Vidarbine Absorption

Not absorbed orally, crosses blood brain barrier.

Vidarbine side effects and Toxicity

LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

Vidarbine Patient Information

BC Cancer

Vidarbine Organisms Affected

Humans and other mammals