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Nipent Brand names, Nipent Analogs

Nipent Brand Names Mixture

  • No information avaliable

Nipent Chemical_Formula


Nipent RX_link

No information avaliable

Nipent fda sheet

Nipent msds (material safety sheet)

Nipent MSDS

Nipent Synthesis Reference

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

Nipent Molecular Weight

268.269 g/mol

Nipent Melting Point

220 oC

Nipent H2O Solubility

30 mg/mL

Nipent State


Nipent LogP


Nipent Dosage Forms

Powder for solution

Nipent Indication

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Nipent Pharmacology

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Nipent Absorption

Not absorbed orally, crosses blood brain barrier.

Nipent side effects and Toxicity

LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

Nipent Patient Information

BC Cancer

Nipent Organisms Affected

Humans and other mammals