Nipent

• Immunosuppressive Agents
• Antibiotics
• Antineoplastic Agents
• ATC:L01XX08

• 2'-DCF
• 2'-Deoxycoformycin
• 2'-Dexoycoformycin
• Co-V
• Co-Vidarabine
• Covidarabine
• Dcf
• Deaminase Inhibitor
• Deoxycoformycin
• Nipent
• PD-ADI
• Vidarbine
• Vira a Deaminase Inhibitor

• No information avaliable

C₁₁H₁₆N₄O₄

No information avaliable

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=111

Nipent MSDS

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

268.269 g/mol

220 ^oC

30 mg/mL

Solid

-1.58

Powder for solution

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Not absorbed orally, crosses blood brain barrier.

LD₅₀=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

BC Cancer

Humans and other mammals