Nipent
Nipent Brand names, Nipent Analogs
Nipent Brand Names Mixture
- No information avaliable
Nipent Chemical_Formula
C11H16N4O4
Nipent RX_link
No information avaliable
Nipent fda sheet
Nipent msds (material safety sheet)
Nipent Synthesis Reference
Showalter, HD et al., J. Med. Chem. 26:1478 (1983)
Nipent Molecular Weight
268.269 g/mol
Nipent Melting Point
220 oC
Nipent H2O Solubility
30 mg/mL
Nipent State
Solid
Nipent LogP
-1.58
Nipent Dosage Forms
Powder for solution
Nipent Indication
For the treatment of hairy cell leukaemia refractory to alpha interferon.
Nipent Pharmacology
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
Nipent Absorption
Not absorbed orally, crosses blood brain barrier.
Nipent side effects and Toxicity
LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
Nipent Patient Information
Nipent Organisms Affected
Humans and other mammals
