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Co-Vidarabine Brand names, Co-Vidarabine Analogs

Co-Vidarabine Brand Names Mixture

  • No information avaliable

Co-Vidarabine Chemical_Formula


Co-Vidarabine RX_link

No information avaliable

Co-Vidarabine fda sheet

Co-Vidarabine msds (material safety sheet)

Co-Vidarabine MSDS

Co-Vidarabine Synthesis Reference

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

Co-Vidarabine Molecular Weight

268.269 g/mol

Co-Vidarabine Melting Point

220 oC

Co-Vidarabine H2O Solubility

30 mg/mL

Co-Vidarabine State


Co-Vidarabine LogP


Co-Vidarabine Dosage Forms

Powder for solution

Co-Vidarabine Indication

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Co-Vidarabine Pharmacology

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Co-Vidarabine Absorption

Not absorbed orally, crosses blood brain barrier.

Co-Vidarabine side effects and Toxicity

LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

Co-Vidarabine Patient Information

BC Cancer

Co-Vidarabine Organisms Affected

Humans and other mammals