Co-Vidarabine
Co-Vidarabine Brand names, Co-Vidarabine Analogs
Co-Vidarabine Brand Names Mixture
- No information avaliable
Co-Vidarabine Chemical_Formula
C11H16N4O4
Co-Vidarabine RX_link
No information avaliable
Co-Vidarabine fda sheet
Co-Vidarabine msds (material safety sheet)
Co-Vidarabine Synthesis Reference
Showalter, HD et al., J. Med. Chem. 26:1478 (1983)
Co-Vidarabine Molecular Weight
268.269 g/mol
Co-Vidarabine Melting Point
220 oC
Co-Vidarabine H2O Solubility
30 mg/mL
Co-Vidarabine State
Solid
Co-Vidarabine LogP
-1.58
Co-Vidarabine Dosage Forms
Powder for solution
Co-Vidarabine Indication
For the treatment of hairy cell leukaemia refractory to alpha interferon.
Co-Vidarabine Pharmacology
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
Co-Vidarabine Absorption
Not absorbed orally, crosses blood brain barrier.
Co-Vidarabine side effects and Toxicity
LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
Co-Vidarabine Patient Information
Co-Vidarabine Organisms Affected
Humans and other mammals
