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Covidarabine Brand names, Covidarabine Analogs

Covidarabine Brand Names Mixture

  • No information avaliable

Covidarabine Chemical_Formula


Covidarabine RX_link

No information avaliable

Covidarabine fda sheet

Covidarabine msds (material safety sheet)

Covidarabine MSDS

Covidarabine Synthesis Reference

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

Covidarabine Molecular Weight

268.269 g/mol

Covidarabine Melting Point

220 oC

Covidarabine H2O Solubility

30 mg/mL

Covidarabine State


Covidarabine LogP


Covidarabine Dosage Forms

Powder for solution

Covidarabine Indication

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Covidarabine Pharmacology

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Covidarabine Absorption

Not absorbed orally, crosses blood brain barrier.

Covidarabine side effects and Toxicity

LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

Covidarabine Patient Information

BC Cancer

Covidarabine Organisms Affected

Humans and other mammals