Deaminase Inhibitor
Deaminase Inhibitor Brand names, Deaminase Inhibitor Analogs
Deaminase Inhibitor Brand Names Mixture
- No information avaliable
Deaminase Inhibitor Chemical_Formula
C11H16N4O4
Deaminase Inhibitor RX_link
No information avaliable
Deaminase Inhibitor fda sheet
Deaminase Inhibitor msds (material safety sheet)
Deaminase Inhibitor Synthesis Reference
Showalter, HD et al., J. Med. Chem. 26:1478 (1983)
Deaminase Inhibitor Molecular Weight
268.269 g/mol
Deaminase Inhibitor Melting Point
220 oC
Deaminase Inhibitor H2O Solubility
30 mg/mL
Deaminase Inhibitor State
Solid
Deaminase Inhibitor LogP
-1.58
Deaminase Inhibitor Dosage Forms
Powder for solution
Deaminase Inhibitor Indication
For the treatment of hairy cell leukaemia refractory to alpha interferon.
Deaminase Inhibitor Pharmacology
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
Deaminase Inhibitor Absorption
Not absorbed orally, crosses blood brain barrier.
Deaminase Inhibitor side effects and Toxicity
LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
Deaminase Inhibitor Patient Information
Deaminase Inhibitor Organisms Affected
Humans and other mammals
