Deaminase Inhibitor en es it fr

Deaminase Inhibitor Brand names, Deaminase Inhibitor Analogs

Deaminase Inhibitor Brand Names Mixture

  • No information avaliable

Deaminase Inhibitor Chemical_Formula

C11H16N4O4

Deaminase Inhibitor RX_link

No information avaliable

Deaminase Inhibitor fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=111

Deaminase Inhibitor msds (material safety sheet)

Deaminase_Inhibitor MSDS

Deaminase Inhibitor Synthesis Reference

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

Deaminase Inhibitor Molecular Weight

268.269 g/mol

Deaminase Inhibitor Melting Point

220 oC

Deaminase Inhibitor H2O Solubility

30 mg/mL

Deaminase Inhibitor State

Solid

Deaminase Inhibitor LogP

-1.58

Deaminase Inhibitor Dosage Forms

Powder for solution

Deaminase Inhibitor Indication

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Deaminase Inhibitor Pharmacology

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Deaminase Inhibitor Absorption

Not absorbed orally, crosses blood brain barrier.

Deaminase Inhibitor side effects and Toxicity

LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

Deaminase Inhibitor Patient Information

BC Cancer

Deaminase Inhibitor Organisms Affected

Humans and other mammals