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Deoxycoformycin Brand names, Deoxycoformycin Analogs

Deoxycoformycin Brand Names Mixture

  • No information avaliable

Deoxycoformycin Chemical_Formula


Deoxycoformycin RX_link

No information avaliable

Deoxycoformycin fda sheet

Deoxycoformycin msds (material safety sheet)

Deoxycoformycin MSDS

Deoxycoformycin Synthesis Reference

Showalter, HD et al., J. Med. Chem. 26:1478 (1983)

Deoxycoformycin Molecular Weight

268.269 g/mol

Deoxycoformycin Melting Point

220 oC

Deoxycoformycin H2O Solubility

30 mg/mL

Deoxycoformycin State


Deoxycoformycin LogP


Deoxycoformycin Dosage Forms

Powder for solution

Deoxycoformycin Indication

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Deoxycoformycin Pharmacology

Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Deoxycoformycin Absorption

Not absorbed orally, crosses blood brain barrier.

Deoxycoformycin side effects and Toxicity

LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

Deoxycoformycin Patient Information

BC Cancer

Deoxycoformycin Organisms Affected

Humans and other mammals