Deoxycoformycin
Deoxycoformycin Brand names, Deoxycoformycin Analogs
Deoxycoformycin Brand Names Mixture
- No information avaliable
Deoxycoformycin Chemical_Formula
C11H16N4O4
Deoxycoformycin RX_link
No information avaliable
Deoxycoformycin fda sheet
Deoxycoformycin msds (material safety sheet)
Deoxycoformycin Synthesis Reference
Showalter, HD et al., J. Med. Chem. 26:1478 (1983)
Deoxycoformycin Molecular Weight
268.269 g/mol
Deoxycoformycin Melting Point
220 oC
Deoxycoformycin H2O Solubility
30 mg/mL
Deoxycoformycin State
Solid
Deoxycoformycin LogP
-1.58
Deoxycoformycin Dosage Forms
Powder for solution
Deoxycoformycin Indication
For the treatment of hairy cell leukaemia refractory to alpha interferon.
Deoxycoformycin Pharmacology
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
Deoxycoformycin Absorption
Not absorbed orally, crosses blood brain barrier.
Deoxycoformycin side effects and Toxicity
LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
Deoxycoformycin Patient Information
Deoxycoformycin Organisms Affected
Humans and other mammals
