Norguaiaretic acid, dihydro-

Norguaiaretic acid, dihydro- Brand names, Norguaiaretic acid, dihydro- Analogs

Norguaiaretic acid, dihydro- Brand Names Mixture

No information avaliable

Norguaiaretic acid, dihydro- Chemical_Formula

C₂₂H₃₀O₃

Norguaiaretic acid, dihydro- RX_link

http://www.rxlist.com/cgi/generic4/megace_es.htm

Norguaiaretic acid, dihydro- fda sheet

Norguaiaretic_acid,_dihydro- FDA

Norguaiaretic acid, dihydro- msds (material safety sheet)

Norguaiaretic_acid,_dihydro- MSDS

Norguaiaretic acid, dihydro- Synthesis Reference

No information avaliable

Norguaiaretic acid, dihydro- Molecular Weight

342.472 g/mol

Norguaiaretic acid, dihydro- Melting Point

218.0-220.0^oC

Norguaiaretic acid, dihydro- H₂O Solubility

2 µg/mL (at 37°C for the acetate salt)

Norguaiaretic acid, dihydro- State

Solid

Norguaiaretic acid, dihydro- LogP

3.123

Norguaiaretic acid, dihydro- Dosage Forms

Oral suspension containing 125 mg of megestrol acetate per mL; Tablet

Norguaiaretic acid, dihydro- Indication

For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used to treat breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.

Norguaiaretic acid, dihydro- Pharmacology

Megestrol is a synthetic progestin and has the same physiologic effects as natural progesterone. The precise mechanism of megestrol’s antianorexic and anticachetic effects is unknown. Initially developed as a contraceptive, it was first evaluated in breast cancer treatment in 1967.

Norguaiaretic acid, dihydro- Absorption

Variable, but well absorbed orally.

Norguaiaretic acid, dihydro- side effects and Toxicity

No serious unexpected side effects have resulted from studies involving megestrol acetate oral suspension administered in dosages as high as 1200 mg/day.

Norguaiaretic acid, dihydro- Patient Information