Nordihydroguairaretic acid
Brand names,
Nordihydroguairaretic acid
Analogs
Nordihydroguairaretic acid
Brand Names Mixture
Nordihydroguairaretic acid
Chemical_Formula
C22H30O3
Nordihydroguairaretic acid
RX_link
http://www.rxlist.com/cgi/generic4/megace_es.htm
Nordihydroguairaretic acid
fda sheet
Nordihydroguairaretic acid
msds (material safety sheet)
Nordihydroguairaretic acid
Synthesis Reference
No information avaliable
Nordihydroguairaretic acid
Molecular Weight
342.472 g/mol
Nordihydroguairaretic acid
Melting Point
218.0-220.0oC
Nordihydroguairaretic acid
H2O Solubility
2 µg/mL (at 37°C for the acetate salt)
Nordihydroguairaretic acid
State
Solid
Nordihydroguairaretic acid
LogP
3.123
Nordihydroguairaretic acid
Dosage Forms
Oral suspension containing 125 mg of megestrol acetate per mL; Tablet
Nordihydroguairaretic acid
Indication
For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used to treat breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
Nordihydroguairaretic acid
Pharmacology
Megestrol is a synthetic progestin and has the same physiologic effects as natural progesterone. The precise mechanism of megestrol’s antianorexic and anticachetic effects is unknown. Initially developed as a contraceptive, it was first evaluated in breast cancer treatment in 1967.
Nordihydroguairaretic acid
Absorption
Variable, but well absorbed orally.
Nordihydroguairaretic acid
side effects and Toxicity
No serious unexpected side effects have resulted from studies involving megestrol acetate oral suspension administered in dosages as high as 1200 mg/day.
Nordihydroguairaretic acid
Patient Information
No information avaliable
Nordihydroguairaretic acid
Organisms Affected
Humans and other mammals