Dinorguaiaretic acid, dihydro-
Dinorguaiaretic acid, dihydro- Brand names, Dinorguaiaretic acid, dihydro- Analogs
Dinorguaiaretic acid, dihydro- Brand Names Mixture
- No information avaliable
Dinorguaiaretic acid, dihydro- Chemical_Formula
C22H30O3
Dinorguaiaretic acid, dihydro- RX_link
http://www.rxlist.com/cgi/generic4/megace_es.htm
Dinorguaiaretic acid, dihydro- fda sheet
Dinorguaiaretic acid, dihydro- msds (material safety sheet)
Dinorguaiaretic acid, dihydro- Synthesis Reference
No information avaliable
Dinorguaiaretic acid, dihydro- Molecular Weight
342.472 g/mol
Dinorguaiaretic acid, dihydro- Melting Point
218.0-220.0oC
Dinorguaiaretic acid, dihydro- H2O Solubility
2 µg/mL (at 37°C for the acetate salt)
Dinorguaiaretic acid, dihydro- State
Solid
Dinorguaiaretic acid, dihydro- LogP
3.123
Dinorguaiaretic acid, dihydro- Dosage Forms
Oral suspension containing 125 mg of megestrol acetate per mL; Tablet
Dinorguaiaretic acid, dihydro- Indication
For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used to treat breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
Dinorguaiaretic acid, dihydro- Pharmacology
Megestrol is a synthetic progestin and has the same physiologic effects as natural progesterone. The precise mechanism of megestrol’s antianorexic and anticachetic effects is unknown. Initially developed as a contraceptive, it was first evaluated in breast cancer treatment in 1967.
Dinorguaiaretic acid, dihydro- Absorption
Variable, but well absorbed orally.
Dinorguaiaretic acid, dihydro- side effects and Toxicity
No serious unexpected side effects have resulted from studies involving megestrol acetate oral suspension administered in dosages as high as 1200 mg/day.
Dinorguaiaretic acid, dihydro- Patient Information
No information avaliable
Dinorguaiaretic acid, dihydro- Organisms Affected
Humans and other mammals
