Dihydronorguaiaretic acid
Brand names,
Dihydronorguaiaretic acid
Analogs
Dihydronorguaiaretic acid
Brand Names Mixture
Dihydronorguaiaretic acid
Chemical_Formula
C22H30O3
Dihydronorguaiaretic acid
RX_link
http://www.rxlist.com/cgi/generic4/megace_es.htm
Dihydronorguaiaretic acid
fda sheet
Dihydronorguaiaretic acid
msds (material safety sheet)
Dihydronorguaiaretic acid
Synthesis Reference
No information avaliable
Dihydronorguaiaretic acid
Molecular Weight
342.472 g/mol
Dihydronorguaiaretic acid
Melting Point
218.0-220.0oC
Dihydronorguaiaretic acid
H2O Solubility
2 µg/mL (at 37°C for the acetate salt)
Dihydronorguaiaretic acid
State
Solid
Dihydronorguaiaretic acid
LogP
3.123
Dihydronorguaiaretic acid
Dosage Forms
Oral suspension containing 125 mg of megestrol acetate per mL; Tablet
Dihydronorguaiaretic acid
Indication
For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used to treat breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
Dihydronorguaiaretic acid
Pharmacology
Megestrol is a synthetic progestin and has the same physiologic effects as natural progesterone. The precise mechanism of megestrol’s antianorexic and anticachetic effects is unknown. Initially developed as a contraceptive, it was first evaluated in breast cancer treatment in 1967.
Dihydronorguaiaretic acid
Absorption
Variable, but well absorbed orally.
Dihydronorguaiaretic acid
side effects and Toxicity
No serious unexpected side effects have resulted from studies involving megestrol acetate oral suspension administered in dosages as high as 1200 mg/day.
Dihydronorguaiaretic acid
Patient Information
No information avaliable
Dihydronorguaiaretic acid
Organisms Affected
Humans and other mammals