NDGA
Brand names,
NDGA
Analogs
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Brand Names Mixture
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Chemical_Formula
C22H30O3
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RX_link
http://www.rxlist.com/cgi/generic4/megace_es.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
342.472 g/mol
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Melting Point
218.0-220.0oC
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H2O Solubility
2 µg/mL (at 37°C for the acetate salt)
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State
Solid
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LogP
3.123
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Dosage Forms
Oral suspension containing 125 mg of megestrol acetate per mL; Tablet
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Indication
For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used to treat breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
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Pharmacology
Megestrol is a synthetic progestin and has the same physiologic effects as natural progesterone. The precise mechanism of megestrol’s antianorexic and anticachetic effects is unknown. Initially developed as a contraceptive, it was first evaluated in breast cancer treatment in 1967.
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Absorption
Variable, but well absorbed orally.
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side effects and Toxicity
No serious unexpected side effects have resulted from studies involving megestrol acetate oral suspension administered in dosages as high as 1200 mg/day.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals