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Lamivudine en es it fr

Lamivudine Brand names, Lamivudine Analogs

Lamivudine Brand Names Mixture

  • Combivir (Lamivudine + Zidovudine)
  • Kivexa (Abacavir (Abacavir Sulfate) + Lamivudine)
  • Trizivir (Abacavir (Abacavir Sulfate) + Lamivudine + Zidovudine)

Lamivudine Chemical_Formula

C8H11N3O3S

Lamivudine RX_link

http://www.rxlist.com/cgi/generic3/lamivudine.htm

Lamivudine fda sheet

Lamivudine FDA

Lamivudine msds (material safety sheet)

Lamivudine MSDS

Lamivudine Synthesis Reference

No information avaliable

Lamivudine Molecular Weight

229.257 g/mol

Lamivudine Melting Point

160-162 oC

Lamivudine H2O Solubility

70 mg/ml

Lamivudine State

Solid

Lamivudine LogP

No information avaliable

Lamivudine Dosage Forms

Solution; Tablet

Lamivudine Indication

For the treatment of HIV infection and chronic hepatitis B (HBV).

Lamivudine Pharmacology

Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

Lamivudine Absorption

Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in adults is 86% ± 16% for the tablet and 87% ± 13% for the oral solution.

Lamivudine side effects and Toxicity

No information avaliable

Lamivudine Patient Information

Lamivudine Organisms Affected

Human immunodeficiency virus and Hepatitis B virus