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Epivir Brand names, Epivir Analogs

Epivir Brand Names Mixture

  • Combivir (Lamivudine + Zidovudine)
  • Kivexa (Abacavir (Abacavir Sulfate) + Lamivudine)
  • Trizivir (Abacavir (Abacavir Sulfate) + Lamivudine + Zidovudine)

Epivir Chemical_Formula

C8H11N3O3S

Epivir RX_link

http://www.rxlist.com/cgi/generic3/lamivudine.htm

Epivir fda sheet

Epivir FDA

Epivir msds (material safety sheet)

Epivir MSDS

Epivir Synthesis Reference

No information avaliable

Epivir Molecular Weight

229.257 g/mol

Epivir Melting Point

160-162 oC

Epivir H2O Solubility

70 mg/ml

Epivir State

Solid

Epivir LogP

No information avaliable

Epivir Dosage Forms

Solution; Tablet

Epivir Indication

For the treatment of HIV infection and chronic hepatitis B (HBV).

Epivir Pharmacology

Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

Epivir Absorption

Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in adults is 86% ± 16% for the tablet and 87% ± 13% for the oral solution.

Epivir side effects and Toxicity

No information avaliable

Epivir Patient Information

Epivir Organisms Affected

Human immunodeficiency virus and Hepatitis B virus